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Histology of human alveolar bone regeneration with a porous tricalcium phosphate

Identifieur interne : 008990 ( Main/Exploration ); précédent : 008989; suivant : 008991

Histology of human alveolar bone regeneration with a porous tricalcium phosphate

Auteurs : Ilara R. Zerbo [Pays-Bas] ; Antonius L. J. J. Bronckers [Pays-Bas] ; Gert L. De Lange [Pays-Bas] ; Elisabeth H. Burger [Pays-Bas] ; Gert J. Van Beek [Pays-Bas]

Source :

Clinical Oral Implants Research [ 0905-7161 ] ; 2001-08.

RBID : ISTEX:F4C5D874E94A853217BFAB8B8231386895C6ABE5

English descriptors

Abstract

Abstract: Porous β‐phase tricalcium phosphate particles (pTCP) (Cerasorb®) were used in two patients to restore or augment alveolar bone prior to the placement of dental implants. In one patient, pTCP was used to fill a large alveolar defect in the posterior mandible after the removal of a residual cyst, and in another patient to augment the sinus floor. Biopsies were taken at the time of implant placement, 9.5 and 8 months after grafting, respectively, and processed for hard tissue histology. Goldner‐stained histological sections showed considerable replacement of the bone substitute by bone and bone marrow. In the 9.5 months biopsy of the mandible, 34% of the biopsy consisted of mineralised bone tissue and 29% of remaining pTCP, while the biopsy at 8 months after sinus floor augmentation consisted of 20% mineralised bone and 44% remaining pTCP. Bone and osteoid were lying in close contact with the remaining pTCP and were also seen within the micropores of the grafted particles. Tartrate resistant‐acid phosphatase (TRAP) multinuclear cells, presumably osteoclasts, were found surrounding, within and in close contact with the pTCP particles, suggesting active resorption of the bone substitute. Remodelling of immature woven bone into mature lamellar bone was also found. No histological signs of inflammation were detected. The limited data presented from these two cases suggest that this graft material, possibly by virtue of its porosity and chemical nature, may be a suitable bone substitute that can biodegrade and be replaced by new mineralising bone tissue.

Url:

https://api.istex.fr/document/F4C5D874E94A853217BFAB8B8231386895C6ABE5/fulltext/pdf

DOI: 10.1034/j.1600-0501.2001.012004379.x

Affiliations:

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Le document en format XML

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<author><name sortKey="Bronckers, Antonius L J J" sort="Bronckers, Antonius L J J" uniqKey="Bronckers A" first="Antonius L. J. J." last="Bronckers">Antonius L. J. J. Bronckers</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acid phosphatase</term>
<term>Active bone formation</term>
<term>Adverse reactions</term>
<term>Augmentation</term>
<term>Autogenous bone</term>
<term>Autologous bone</term>
<term>Biopsy</term>
<term>Bone defect</term>
<term>Bone deposition</term>
<term>Bone formation</term>
<term>Bone regeneration</term>
<term>Bone substitute</term>
<term>Bone tissue</term>
<term>Bone volume</term>
<term>Burger</term>
<term>Cerasorba</term>
<term>Curasan pharma gmbh</term>
<term>Defect</term>
<term>Dental implant</term>
<term>Dental implants</term>
<term>Engem kontakt</term>
<term>Estrecho contacto</term>
<term>Graft</term>
<term>Graft material</term>
<term>Graft particle</term>
<term>Graft particles</term>
<term>Grafted site</term>
<term>Histological</term>
<term>Histological evaluation</term>
<term>Histological sections</term>
<term>Human alveolar bone regeneration</term>
<term>Human maxillary sinus</term>
<term>Iliac crest</term>
<term>Implant</term>
<term>Implant placement</term>
<term>Lamellar bone</term>
<term>Large amounts</term>
<term>Large bone defects</term>
<term>Mandible</term>
<term>Matrix</term>
<term>Maxillofacial surgery</term>
<term>Meses tras</term>
<term>Mineralised</term>
<term>Mineralised bone</term>
<term>Mineralised bone tissue</term>
<term>Multinuclear cells</term>
<term>Oral impl</term>
<term>Osteoclast</term>
<term>Osteoclastic activity</term>
<term>Osteogenic cells</term>
<term>Osteoid</term>
<term>Porous structure</term>
<term>Porous tricalcium phosphate</term>
<term>Posterior mandible</term>
<term>Power view</term>
<term>Present study</term>
<term>Ptcp</term>
<term>Ptcp granules</term>
<term>Ptcp material</term>
<term>Ptcp particles</term>
<term>Ptcp restante</term>
<term>Regeneration</term>
<term>Sinus</term>
<term>Sinus augmentation</term>
<term>Sinus elevation</term>
<term>Thin strands</term>
<term>Tricalcium</term>
<term>Tricalcium phosphate</term>
<term>Trichrome method</term>
<term>Vrije universiteit</term>
<term>Zerbo</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acid phosphatase</term>
<term>Active bone formation</term>
<term>Adverse reactions</term>
<term>Augmentation</term>
<term>Autogenous bone</term>
<term>Autologous bone</term>
<term>Biopsy</term>
<term>Bone defect</term>
<term>Bone deposition</term>
<term>Bone formation</term>
<term>Bone regeneration</term>
<term>Bone substitute</term>
<term>Bone tissue</term>
<term>Bone volume</term>
<term>Burger</term>
<term>Cerasorba</term>
<term>Curasan pharma gmbh</term>
<term>Defect</term>
<term>Dental implant</term>
<term>Dental implants</term>
<term>Engem kontakt</term>
<term>Estrecho contacto</term>
<term>Graft</term>
<term>Graft material</term>
<term>Graft particle</term>
<term>Graft particles</term>
<term>Grafted site</term>
<term>Histological</term>
<term>Histological evaluation</term>
<term>Histological sections</term>
<term>Human alveolar bone regeneration</term>
<term>Human maxillary sinus</term>
<term>Iliac crest</term>
<term>Implant</term>
<term>Implant placement</term>
<term>Lamellar bone</term>
<term>Large amounts</term>
<term>Large bone defects</term>
<term>Mandible</term>
<term>Matrix</term>
<term>Maxillofacial surgery</term>
<term>Meses tras</term>
<term>Mineralised</term>
<term>Mineralised bone</term>
<term>Mineralised bone tissue</term>
<term>Multinuclear cells</term>
<term>Oral impl</term>
<term>Osteoclast</term>
<term>Osteoclastic activity</term>
<term>Osteogenic cells</term>
<term>Osteoid</term>
<term>Porous structure</term>
<term>Porous tricalcium phosphate</term>
<term>Posterior mandible</term>
<term>Power view</term>
<term>Present study</term>
<term>Ptcp</term>
<term>Ptcp granules</term>
<term>Ptcp material</term>
<term>Ptcp particles</term>
<term>Ptcp restante</term>
<term>Regeneration</term>
<term>Sinus</term>
<term>Sinus augmentation</term>
<term>Sinus elevation</term>
<term>Thin strands</term>
<term>Tricalcium</term>
<term>Tricalcium phosphate</term>
<term>Trichrome method</term>
<term>Vrije universiteit</term>
<term>Zerbo</term>
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<front><div type="abstract">Abstract: Porous β‐phase tricalcium phosphate particles (pTCP) (Cerasorb®) were used in two patients to restore or augment alveolar bone prior to the placement of dental implants. In one patient, pTCP was used to fill a large alveolar defect in the posterior mandible after the removal of a residual cyst, and in another patient to augment the sinus floor. Biopsies were taken at the time of implant placement, 9.5 and 8 months after grafting, respectively, and processed for hard tissue histology. Goldner‐stained histological sections showed considerable replacement of the bone substitute by bone and bone marrow. In the 9.5 months biopsy of the mandible, 34% of the biopsy consisted of mineralised bone tissue and 29% of remaining pTCP, while the biopsy at 8 months after sinus floor augmentation consisted of 20% mineralised bone and 44% remaining pTCP. Bone and osteoid were lying in close contact with the remaining pTCP and were also seen within the micropores of the grafted particles. Tartrate resistant‐acid phosphatase (TRAP) multinuclear cells, presumably osteoclasts, were found surrounding, within and in close contact with the pTCP particles, suggesting active resorption of the bone substitute. Remodelling of immature woven bone into mature lamellar bone was also found. No histological signs of inflammation were detected. The limited data presented from these two cases suggest that this graft material, possibly by virtue of its porosity and chemical nature, may be a suitable bone substitute that can biodegrade and be replaced by new mineralising bone tissue.</div>
</front>
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<affiliations><list><country><li>Pays-Bas</li>
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<name sortKey="Bronckers, Antonius L J J" sort="Bronckers, Antonius L J J" uniqKey="Bronckers A" first="Antonius L. J. J." last="Bronckers">Antonius L. J. J. Bronckers</name>
<name sortKey="Burger, Elisabeth H" sort="Burger, Elisabeth H" uniqKey="Burger E" first="Elisabeth H." last="Burger">Elisabeth H. Burger</name>
<name sortKey="De Lange, Gert L" sort="De Lange, Gert L" uniqKey="De Lange G" first="Gert L." last="De Lange">Gert L. De Lange</name>
<name sortKey="Van Beek, Gert J" sort="Van Beek, Gert J" uniqKey="Van Beek G" first="Gert J." last="Van Beek">Gert J. Van Beek</name>
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Histology of human alveolar bone regeneration with a porous tricalcium phosphate

Histology of human alveolar bone regeneration with a porous tricalcium phosphate

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English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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